蝦青素增加（視網膜）之脈絡膜血流速度

作者：

齋藤M，吉田K，齊藤，富士屋一個，Ohgami K，Kitaichi ñ，冢原石田小號，小號大野。

來源

眼科部，西7丁目，北15柔，北區，札幌060-8638，日本北海道大學研究生院醫學研究。

摘要目的：

此前曾有研究表明，蝦青素（AXT）具有抗氧化和抗炎作用，除了它能夠縮短血液運輸時間。由于激光散斑流量圖（LSFG）可以無創性偵測脈絡膜循環的血流動力學，我們使用這項技術來評估是否連續攝入艾詩特（蝦青素）12毫克/天，能否增加定量血流速度。

方法：

在這項隨機，雙盲，安慰劑對照研究中，我們研究了20名健康志愿者超過4周期間攝入12毫克的艾詩特（AXT）或安慰劑膠囊。LSFG測量前攝入右眼的所有科目，并在艾詩特（AXT）治療2和4周后。用LSFG值來計算平方模糊率（SBR），這是一個相對血流速度的定量指標。

結果：

視網膜黃斑的SBR值在攝入艾詩特（AXT）4周后顯著增加，與攝取前值（Wilcoxon符號秩檢驗，P = 0.018）。與此相反，服用安慰劑的對照組視網膜黃斑的SBR值沒有統計學差異（弗里德曼檢驗，P = 0.598）。服用艾詩特（AXT）12mg/天組未發現任何主觀或客觀的不良事件。

結論：

結果顯示，超過4周期間的艾詩特（AXT）的治療可以提高脈絡膜血流速度無任何不良影響。

Astaxanthin increases choroidal blood flow velocity.

Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S.

Source

Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi-7-chome, Kita 15-jou, Kita-ku, Sapporo, 060-8638, Japan.

Abstract

PURPOSE:

Previous studies have reported that astaxanthin (AXT) has antioxidative and anti-inflammatory effects in addition to its ability to shorten blood transit times. As laser speckle flowgraphy (LSFG) can noninvasively visualize the hemodynamics of the choroidal circulation, we used the technique to evaluate whether continuous ingestion of 12 mg of AXT per day could increase quantitative blood flow velocity.

METHODS:

In this randomized, double-blind, placebo-controlled study, we examined 20 healthy volunteers who ingested 12 mg AXT or placebo capsules over a 4-week period. LSFG was measured in the right eyes of all subjects at pre-ingestion, and at 2 and 4 weeks after the treatment of AXT. LSFG values were used to calculate the square blur rate (SBR), which is a quantitative index of relative blood flow velocity.

RESULTS:

A significant increase of the macular SBR was seen 4 weeks after AXT ingestion when compared to the pre-ingestion values (Wilcoxon signed-rank test, P = 0.018). In contrast, no statistical difference in the macular SBR was detected in the placebo group (Friedman test, P = 0.598). No subjective or objective adverse events were found after the 12-mg AXT ingestion.

CONCLUSIONS:

Results suggest that administration of AXT over a 4-week period can elevate the choroidal blood flow velocity without any adverse effects.